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Headache: Although a migraine headache generally occurs on the one hand of the pinnacle, 30-40% of migraineurs you can keep them on both sides. Aspirin Sinus relief medications Acetaminophen (Tylenol) Non-steroidal anti-inflammatory medications (including Aleve) Sedatives for sleep Codeine and prescription narcotics Over-the-counter combination headache remedies containing caffeine (such as Anacin, Excedrin, Bayer Select) Ergotamine preparations (including Cafergot, Migergot, Ergomar, Bellergal-S, Bel-Phen-Ergot S, Phenerbel-S, Ercaf, Wigraine, and Cafatine PB) Butalbital combination pain-killer (Goody's Headache Powder, Supac, fiorinal, fioricet) The CR report took a really close look in a group of drugs called the triptans, who have become the most often prescribed drug for migraine patients, despite the fact that MDs are unclear about how they work (it's believed they affect what sort of nervous system handles serotonin, that is involved in pain processing). 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